BSJ-04-132

Name: BSJ-04-132
Brand: Tocris Bioscience
SKU: 6937

Tocris Bioscience, part of Bio-Techne | Catalog # 6937

COA / SDS

Selective Cdk4 Degrader (PROTAC®)

Key Product Details

Description:	Selective Cdk4 Degrader (PROTAC^®)
Chemical Name:	7-Cyclopentyl-2-[[5-[4-[4-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]oxy]acetamido]butyl]piperazin-1-yl]pyridin-2-yl]amino]-N,N-dimethyl-7H-pyrrolo[2,3d]pyrimidine-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	819.92

View Full Technical Details for BSJ-04-132

Technical Data
Citations

Biological Activity for BSJ-04-132

BSJ-04-132 is a selective Cdk4 Degrader (PROTAC^®). Degrades Cdk4 in Molt-4 cells, with no effect on Cdk6 levels. Displays cereblon-dependent degradation.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-04-132

M. Wt	819.92
Formula	C₄₂H₄₉N₁₁O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2349356-39-2
InChi Key	GWLSXEHHNOBFOI-UHFFFAOYSA-N
Smiles	O=C(COC1=C2C(C(N(C3C(NC(CC3)=O)=O)C2=O)=O)=CC=C1)NCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC7=C(C=C(C(N(C)C)=O)N7C8CCCC8)C=N6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BSJ-04-132

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	81.99	100

Preparing Stock Solutions for BSJ-04-132

The following data is based on the product molecular weight 819.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.22 mL	6.10 mL	12.20 mL
5 mM	0.24 mL	1.22 mL	2.44 mL
10 mM	0.12 mL	0.61 mL	1.22 mL
50 mM	0.02 mL	0.12 mL	0.24 mL

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References for BSJ-04-132

References are publications that support the biological activity of the product.

Jiang Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 2019 PMID: 30802347