BSJ-4-116

Name: BSJ-4-116
Brand: Tocris Bioscience
SKU: 7528

Tocris Bioscience, part of Bio-Techne | Catalog # 7528

Citations (1)

COA / SDS

Selective CDK12 PROTAC® Degrader

Key Product Details

Chemical Name:	N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:	≥98%

View Full Technical Details for BSJ-4-116

Technical Data
Citations

Biological Activity for BSJ-4-116

BSJ-4-116 is a selective CDK12 PROTAC^® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no degradation of CDK13 or cyclin K. The compound inhibits growth of T-ALL cells and sensitizes them to PARP inhibitor Olaparib (Cat. No. 7579).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for BSJ-4-116

Formula	C₄₀H₄₉ClN₈O₈S
Storage	Store at -20°C
Purity	≥98%
CAS Number	2519823-34-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BSJ-4-116

Solubility

Soluble Soluble to 100 mM in DMSO

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Product Documents for BSJ-4-116

COA

Certificate of Analysis

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