BTD

Name: BTD
Brand: Tocris Bioscience
SKU: 6940

Tocris Bioscience, part of Bio-Techne | Catalog # 6940

Citations (1)

COA / SDS

Selective TRPC5 activator

Key Product Details

Description:	Selective TRPC5 activator
Chemical Name:	6-Methyl-N-[3-(tricyclo[3.3.1.^13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	459.61

View Full Technical Details for BTD

Technical Data
Citations

Biological Activity for BTD

BTD is a selective TRPC5 activator (EC₅₀ = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC₅₀ = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.

Technical Data for BTD

M. Wt	459.61
Formula	C₂₄H₃₃N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	896684-04-1
PubChem ID	46369355
InChi Key	YXADKMPRWFBOHW-UHFFFAOYSA-N
Smiles	CC1=CC=C2C(NC(CCC(=O)NCCCOC34CC5CC(CC(C5)C3)C4)=N[S]2(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTD

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.96	100

Preparing Stock Solutions for BTD

The following data is based on the product molecular weight 459.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.88 mL	21.76 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Molarity Calculator

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Reconstitution Calculator

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References for BTD

References are publications that support the biological activity of the product.

Beckmann A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 2017 PMID: 28807145

BTD