BTT 3033

Name: BTT 3033
Brand: Tocris Bioscience
SKU: 4724
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4724

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Citations (26)

COA / SDS

Selective inhibitor of integrin α2β1

Key Product Details

Description:	Selective inhibitor of integrin α₂β₁
Chemical Name:	1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	465.5

View Full Technical Details for BTT 3033

Technical Data
Citations / Reviews (1)

Biological Activity for BTT 3033

BTT 3033 is a selective inhibitor of integrin α₂β₁ (EC₅₀ = 130 nM for α₂β₁ binding to collagen I). Binds to the α₂I domain. Exhibits selectivity for α₂β₁ over integrins α₃β₁, α₄β₁, α₅β₁ and α_v. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α₂-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A₂-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.

Compound Libraries for BTT 3033

BTT 3033 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BTT 3033

M. Wt	465.5
Formula	C₂₃H₂₀FN₅O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1259028-99-3
PubChem ID	49841251
InChi Key	NSLIQOPYDUKWTA-UHFFFAOYSA-N
Smiles	FC1=CC=C(N2N=CC(S(N(C3=CC=C(NC(NC4=CC=CC=C4)=O)C=C3)C)(=O)=O)=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTT 3033

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.55	100

Preparing Stock Solutions for BTT 3033

The following data is based on the product molecular weight 465.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for BTT 3033

References are publications that support the biological activity of the product.

Li Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells. Ann.Transl.Med. 2021 PMID: 34733932
Nissinen Novel a2 beta 1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol. 2012 PMID: 23132859