BTT 3033

Name: BTT 3033
Brand: Tocris Bioscience
SKU: 4724

Tocris Bioscience, part of Bio-Techne | Catalog # 4724

(1)

Citations (23)

COA / SDS

Selective inhibitor of integrin α2β1

Key Product Details

Chemical Name:	1-(4-Fluorophenyl)-N-methyl-N-[4[[(phenylamino)carbonyl]amino]phenyl]-1H-pyrazole-4-sulfonamide
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for BTT 3033

BTT 3033 is a selective inhibitor of integrin α₂β₁ (EC₅₀ = 130 nM for α₂β₁ binding to collagen I). Binds to the α₂I domain. Exhibits selectivity for α₂β₁ over integrins α₃β₁, α₄β₁, α₅β₁ and α_v. BTT 3033 inhibits platelet aggregation to collagen I coated capillaries under flow and inhibits binding of α₂-expressing CHO cells to collagen I under shear stress conditions. Neurogenic and thromboxane A₂-induced human prostate smooth muscle contraction are also inhibited by BTT 3033.

Technical Data for BTT 3033

Formula	C₂₃H₂₀FN₅O₃S
Storage	Store at +4°C
Purity	≥98%
CAS Number	1259028-99-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BTT 3033

Solubility

Soluble Soluble to 100 mM in DMSO

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References for BTT 3033

References are publications that support the biological activity of the product.

Nissinen et al. Novel a2�1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J.Cell Biol., 2012;287:44694 PMID: 23132859

BTT 3033

Tocris Bioscience, part of Bio-Techne | Catalog # 4724

Key Product Details

Biological Activity for BTT 3033

Technical Data for BTT 3033

Solubility for BTT 3033

Dilution Calculator

Reconstitution Calculator

References for BTT 3033

Product Documents for BTT 3033

COA

Certificate of Analysis

SDS

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