Butabindide oxalate

Name: Butabindide oxalate
Brand: Tocris Bioscience
SKU: 1323

Tocris Bioscience, part of Bio-Techne | Catalog # 1323

Citations (1)

COA / SDS

High affinity CCK-inactivating serine protease inhibitor

Discontinued Product

1323 has been discontinued. View all Additional Synthetic Protease Inhibitors products.

Key Product Details

Description:	High affinity CCK-inactivating serine protease inhibitor
Chemical Name:	(2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	393.44

View Full Technical Details for Butabindide oxalate

Technical Data
Citations

Biological Activity for Butabindide oxalate

Butabindide oxalate is a high affinity, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (K_i = 7 nM). Active in vivo (ID₅₀ = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).

Licensing Information

Sold with the permission of INSERM and UCL

Technical Data for Butabindide oxalate

M. Wt	393.44
Formula	C₁₇H₂₅N₃O₂.C₂H₂O₄
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	185213-03-0
PubChem ID	56972132
InChi Key	KKMJFDVOXSGHBF-SLHAJLBXSA-N
Smiles	O=C(O)C(O)=O.O=[C@]([C@@H](N)CC)N([C@H]([C@@](NCCCC)=O)C2)C1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Butabindide oxalate

References are publications that support the biological activity of the product.

Renn Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster. J.Biol.Chem. 1998 PMID: 9668104
Rose Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature 1996 PMID: 8602240
Ganellin Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J.Med.Chem. 2000 PMID: 10691692