c-JUN peptide

Name: c-JUN peptide
Brand: Tocris Bioscience
SKU: 1989

Tocris Bioscience, part of Bio-Techne | Catalog # 1989

Citations (76)

COA / SDS

Peptide inhibitor of JNK/c-Jun interaction

Key Product Details

Description:	Peptide inhibitor of JNK/c-Jun interaction
Purity:	≥95% (HPLC)
Molecular Weight:	2743.55

View Full Technical Details for c-JUN peptide

Technical Data
Citations

Biological Activity for c-JUN peptide

c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21^cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.

Technical Data for c-JUN peptide

M. Wt	2743.55
Formula	C₁₂₁H₂₁₀N₃₆O₃₄S
Single Letter Sequence	ILKQSMTLNLADPVGSLKPHLRAKN
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	610273-01-3
PubChem ID	90488732
InChi Key	OVPPMIXGVMXSNS-CLIBVNCNSA-N
Smiles	[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for c-JUN peptide

Solubility

Soluble to 1mg/ml in water

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References for c-JUN peptide

References are publications that support the biological activity of the product.

Holzberg Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 2003 PMID: 12832416