C34

Tocris Bioscience, part of Bio-Techne | Catalog # 5373

Citations (23)

COA / SDS

TLR4 inhibitor

Key Product Details

Chemical Name:

1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

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Technical Data
Citations

Biological Activity for C34

C34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

Technical Data for C34

Formula	C₁₇H₂₇NO₉
Storage	Store at -20°C
CAS Number	40592-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C34

Solubility

Soluble Soluble to 50 mM in water and to 100 mM in DMSO

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References for C34

References are publications that support the biological activity of the product.

Neal et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One, 2013;8:e65779 PMID: 23776545

C34

Tocris Bioscience, part of Bio-Techne | Catalog # 5373

Key Product Details

Biological Activity for C34

Technical Data for C34

Solubility for C34

Dilution Calculator

Reconstitution Calculator

References for C34

Product Documents for C34

COA

Certificate of Analysis

SDS

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