C34

Tocris Bioscience, part of Bio-Techne | Catalog # 5373

COA / SDS

TLR4 inhibitor

Key Product Details

Description:	TLR4 inhibitor
Alternative Names:	TLR4-IN-C34
Chemical Name:	1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
Molecular Weight:	389.4

View Full Technical Details for C34

Technical Data
Citations

Biological Activity for C34

C34 is a TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

Compound Libraries for C34

C34 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for C34

M. Wt	389.4
Formula	C₁₇H₂₇NO₉
Storage	Store at -20°C
CAS Number	40592-88-9
PubChem ID	91691128
InChi Key	KMIQMFHPUJUDMC-HHARLNAUSA-N
Smiles	CC(OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](NC(C)=O)[C@@H](OC(C)C)O1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C34

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	19.47	50
	DMSO	38.94	100

Preparing Stock Solutions for C34

The following data is based on the product molecular weight 389.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Molarity Calculator

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Reconstitution Calculator

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References for C34

References are publications that support the biological activity of the product.

Neal Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One 2013 PMID: 23776545

C34