Cabergoline

Name: Cabergoline
Brand: Tocris Bioscience
SKU: 2664

Tocris Bioscience, part of Bio-Techne | Catalog # 2664

Citations (13)

COA / SDS

D2-like agonist (D2>D3>D4)

Key Product Details

Chemical Name:	N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8-carboxamide
Purity:	≥99%
Molecular Weight:	451.6 kDa

View Full Technical Details for Cabergoline

Technical Data
Citations

Biological Activity for Cabergoline

Cabergoline is a selective D₂-like dopamine receptor agonist (K_i values are 0.7, 1.5, 9.0 and 165 nM for D₂, D₃, D₄ and D₅ receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K_i = 1.2 - 20.0 nM for 5-HT_1A, 5-HT_1D, 5-HT_2A and 5-HT_2B). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.

Technical Data for Cabergoline

M. Wt	451.6 kDa
Formula	C₂₆H₃₇N₅O₂
Storage	Store at +4°C
Purity	≥99%
CAS Number	81409-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cabergoline

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Cabergoline

References are publications that support the biological activity of the product.

Eguchi et al. Effect of cabergoline, a DA agonist, on estrogen-induced rat pituitary tumors:in vitro culture studies. Endocr.J., 1995;42:413 PMID: 7670571
Kvernmo et al. A review of the receptor-binding and pharmacokinetic properties of DA agonists. Clin.Ther., 2006;28:1065 PMID: 16982285
Hadj Tahar et al. Sustained caberg. treatment reverses levodopa-induced dyskinesias in parkinsonian monkeys. Cin.Neuropharmacol., 2000;23:195