Calmidazolium chloride

Name: Calmidazolium chloride
Brand: Tocris Bioscience
SKU: 2561

Tocris Bioscience, part of Bio-Techne | Catalog # 2561

Citations (6)

COA / SDS

Calmodulin antagonist

Key Product Details

Description:	Calmodulin antagonist
Alternative Names:	R 24571
Chemical Name:	1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride
Purity:	≥95% (HPLC)
Molecular Weight:	687.7

View Full Technical Details for Calmidazolium chloride

Technical Data
Citations

Biological Activity for Calmidazolium chloride

Calmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca²⁺-transporting ATPase with IC₅₀ values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Technical Data for Calmidazolium chloride

M. Wt	687.7
Formula	C₃₁H₂₃Cl₇N₂O
Storage	Store at +4°C
Purity	≥95% (HPLC)
CAS Number	57265-65-3
PubChem ID	644274
InChi Key	YGEIMSMISRCBFF-UHFFFAOYSA-M
Smiles	[Cl-].ClC1=CC=C(C=C1)C(N1C=C[N+](CC(OCC2=CC=C(Cl)C=C2Cl)C2=CC=C(Cl)C=C2Cl)=C1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Calmidazolium chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	68.77	100
	ethanol	68.77	100

Preparing Stock Solutions for Calmidazolium chloride

The following data is based on the product molecular weight 687.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.45 mL	7.27 mL	14.54 mL
5 mM	0.29 mL	1.45 mL	2.91 mL
10 mM	0.15 mL	0.73 mL	1.45 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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References for Calmidazolium chloride

References are publications that support the biological activity of the product.

Harper and Daly Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 2000 PMID: 10856426
Peppiatt Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 2004 PMID: 15130089
Gietzen Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 1983 PMID: 6141789