Calyculin A

Name: Calyculin A
Brand: Tocris Bioscience
SKU: 1336
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1336

(1)

Citations (48)

COA / SDS

Protein phosphatase 1 and 2A inhibitor

Key Product Details

Description:	Protein phosphatase 1 and 2A inhibitor
Chemical Name:	N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
Purity:	≥97% (HPLC)
Molecular Weight:	1009.18

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Technical Data
Citations / Reviews (1)

Biological Activity for Calyculin A

Calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC₅₀ = 0.3 - 0.7 nM) and protein phosphatase 2A (IC₅₀ = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Note: This product is typically prepared in DMSO.

Technical Data for Calyculin A

M. Wt	1009.18
Formula	C₅₀H₈₁N₄O₁₅P
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	101932-71-2
PubChem ID	3894
InChi Key	ULTTYPMRMMDONC-UHFFFAOYSA-N
Smiles	O[C@H]1[C@H](C)[C@H](C/C=C/C3=COC([C@@H](C)CCNC([C@H]([C@H]([C@@H](N(C)C)COC)O)O)=O)=N3)O[C@]2([C@](C)(C)[C@@H](OP(O)(O)=O)[C@]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)([H])O2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Calyculin A

References are publications that support the biological activity of the product.

McCluskey Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 2002 PMID: 11881984
Ishihara Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem.Biophys.Res.Commun. 1989 PMID: 2539153
Lindval The binding mode of calyculin A to protein phosphatase-1. J.Biol.Chem. 1997 PMID: 9287341
Favre Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J.Biol.Chem. 1997 PMID: 9153244

Calyculin A

Tocris Bioscience, part of Bio-Techne | Catalog # 1336

Key Product Details

Biological Activity for Calyculin A

Technical Data for Calyculin A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Calyculin A

Product Documents for Calyculin A

COA

Certificate of Analysis

SDS

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