Camptothecin

Name: Camptothecin
Brand: Tocris Bioscience
SKU: 1100

Tocris Bioscience, part of Bio-Techne | Catalog # 1100

Citations (63)

COA / SDS

DNA topoisomerase inhibitor

Key Product Details

Description:	DNA topoisomerase inhibitor
Chemical Name:	(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	348.36

View Full Technical Details for Camptothecin

Technical Data
Citations

Biological Activity for Camptothecin

Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

Technical Data for Camptothecin

M. Wt	348.36
Formula	C₂₀H₁₆N₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	7689-03-4
PubChem ID	24360
InChi Key	VSJKWCGYPAHWDS-FQEVSTJZSA-N
Smiles	O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Camptothecin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		5

Preparing Stock Solutions for Camptothecin

The following data is based on the product molecular weight 348.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	57.41 mL	287.06 mL	574.12 mL
0.25 mM	11.48 mL	57.41 mL	114.82 mL
0.5 mM	5.74 mL	28.71 mL	57.41 mL
2.5 mM	1.15 mL	5.74 mL	11.48 mL

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Reconstitution Calculator

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References for Camptothecin

References are publications that support the biological activity of the product.

Hsiang Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 1985 PMID: 2997227
Pantazis Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 1993 PMID: 8449612
Liu DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 1989 PMID: 2549853