CBR-470-1

Name: CBR-470-1
Brand: Tocris Bioscience
SKU: 7018

Tocris Bioscience, part of Bio-Techne | Catalog # 7018

Citations (2)

COA / SDS

PGK1 inhibitor; activates Nrf2

Key Product Details

Chemical Name:	(3R,4S)-rel-4-[(4-Chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-3-thiophenamine-1,1-dioxide
Purity:	≥98%

View Full Technical Details for CBR-470-1

Technical Data
Citations

Biological Activity for CBR-470-1

CBR-470-1 is a phosphoglycerate kinase 1 (PGK1) inhibitor. CBR-470-1 promotes accumulation of the reactive metabolites methylglyoxal (MGO) resulting in KEAP1 modification and dimerization, which in turn leads to activation of the Nrf2 transcriptional program. CBR-470-1 protects SH-SY5Y neuroblastoma cells from MPP⁺-induced cytotoxicity via the Keap1-Nrf2 cascade.

Technical Data for CBR-470-1

Formula	C₁₄H₂₀ClNO₄S₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	2416095-06-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CBR-470-1

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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Product Documents for CBR-470-1

COA

Certificate of Analysis

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