CD 2314

Name: CD 2314
Brand: Tocris Bioscience
SKU: 3824

Tocris Bioscience, part of Bio-Techne | Catalog # 3824

Citations (17)

COA / SDS

Selective RARβ agonist

Key Product Details

Description:	Selective RARβ agonist
Chemical Name:	5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	364.5

View Full Technical Details for CD 2314

Technical Data
Citations

Biological Activity for CD 2314

CD 2314 is a potent and selective RARβ receptor agonist (K_dvalues are 145 and >3760 nM for RARβ and RARα receptors respectively; no binding detected at RARγ). Inhibits growth of human HNSCC 22B, 183A and 22A cells (IC₅₀ values are 3.0, 5.7 and 8.0 μM respectively).

Compound Libraries for CD 2314

CD 2314 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CD 2314

M. Wt	364.5
Formula	C₂₃H₂₄O₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	170355-37-0
PubChem ID	15293210
InChi Key	URUSABQSUCBGGJ-UHFFFAOYSA-N
Smiles	CC(CCC(C)4C)(C)C1=C4C=C(C=CC(C3=CC(C(O)=O)=CS3)=C2)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD 2314

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.45	100

Preparing Stock Solutions for CD 2314

The following data is based on the product molecular weight 364.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.43 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Reconstitution Calculator

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References for CD 2314

References are publications that support the biological activity of the product.

Szondy Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem.J. 1998 PMID: 9560303
Zhao Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10. Cancer Res. 2009 PMID: 19470764
Sun Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin.Cancer Res. 2000 PMID: 10778990