CD 437

Name: CD 437
Brand: Tocris Bioscience
SKU: 1549

Tocris Bioscience, part of Bio-Techne | Catalog # 1549

Citations (20)

COA / SDS

RARγ-selective agonist

Key Product Details

Description:	RARγ-selective agonist
Alternative Names:	AHPN
Chemical Name:	6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	398.5

View Full Technical Details for CD 437

Technical Data
Citations

Biological Activity for CD 437

CD 437 is a synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.

Compound Libraries for CD 437

CD 437 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CD 437

M. Wt	398.5
Formula	C₂₇H₂₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	125316-60-1
PubChem ID	135411
InChi Key	LDGIHZJOIQSHPB-UHFFFAOYSA-N
Smiles	OC(=O)C1=CC=C2C=C(C=CC2=C1)C1=CC=C(O)C(=C1)C12CC3CC(CC(C3)C1)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CD 437

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	7.97	20
	DMSO	39.85	100

Preparing Stock Solutions for CD 437

The following data is based on the product molecular weight 398.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.09 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for CD 437

References are publications that support the biological activity of the product.

Wang Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 2011 PMID: 21990348
Zhao and Spanjaard The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 2003 PMID: 12566985