CDN 1163

Name: CDN 1163
Brand: Tocris Bioscience
SKU: 5869

Tocris Bioscience, part of Bio-Techne | Catalog # 5869

Citations (6)

COA / SDS

SERCA2 allosteric activator

Key Product Details

Description:	SERCA2 allosteric activator
Chemical Name:	4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	320.38

View Full Technical Details for CDN 1163

Technical Data
Citations

Biological Activity for CDN 1163

CDN 1163 is a SERCA2 allosteric activator. Increases Ca²⁺-ATPase activity and Ca²⁺ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective, improves memory and cognition in a mouse Alzheimer's disease model and reduces dyskinesia in rat model of Parkinson's disease. Orally bioavailable.

Compound Libraries for CDN 1163

CDN 1163 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CDN 1163

M. Wt	320.38
Formula	C₂₀H₂₀N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	892711-75-0
PubChem ID	16016585
InChi Key	GVGVYDCVFBGALZ-UHFFFAOYSA-N
Smiles	CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CDN 1163

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.04	100
	ethanol	32.04	100

Preparing Stock Solutions for CDN 1163

The following data is based on the product molecular weight 320.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for CDN 1163

References are publications that support the biological activity of the product.

Krajnak and Dahl A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg.Med.Chem.Lett. 2018 PMID: 29602679
Dahl A new target for Parkinson's disease: small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg.Med.Chem.Lett. 2017 PMID: 27776889
Kang Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 2016 PMID: 26702054