CE3F4

Name: CE3F4
Brand: Tocris Bioscience
SKU: 4793

Tocris Bioscience, part of Bio-Techne | Catalog # 4793

Citations (23)

COA / SDS

Noncompetitive Epac1 inhibitor

Key Product Details

Description:	Noncompetitive Epac1 inhibitor
Chemical Name:	5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity:	≥98% (HPLC)
Molecular Weight:	351.01

View Full Technical Details for CE3F4

Technical Data
Citations

Biological Activity for CE3F4

CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.

Compound Libraries for CE3F4

CE3F4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CE3F4

M. Wt	351.01
Formula	C₁₁H₁₀Br₂FNO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	143703-25-7
PubChem ID	21781066
InChi Key	ZZLQPWXVZCPUGC-UHFFFAOYSA-N
Smiles	BrC1=C(F)C(Br)=C(CCC(C)N2C=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CE3F4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.1	100
	ethanol	17.55	50

Preparing Stock Solutions for CE3F4

The following data is based on the product molecular weight 351.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.24 mL	28.49 mL
5 mM	0.57 mL	2.85 mL	5.70 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for CE3F4

References are publications that support the biological activity of the product.

Courilleau Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 2012 PMID: 23139415
Chen The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain. Ann.Transl.Med.
Laurent Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 2015 PMID: 25411381