Centrinone B

Name: Centrinone B
Brand: Tocris Bioscience
SKU: 5690
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5690

(1)

Citations (25)

COA / SDS

High affinity and selective PLK4 inhibitor

Key Product Details

Description:	High affinity and selective PLK4 inhibitor
Alternative Names:	LCR 323
Chemical Name:	2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	631.67

View Full Technical Details for Centrinone B

Technical Data
Citations / Reviews (1)

Biological Activity for Centrinone B

Centrinone B is a high affinity and selective PLK4 inhibitor (K_i = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Technical Data for Centrinone B

M. Wt	631.67
Formula	C₂₇H₂₇F₂N₇O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1798871-31-4
PubChem ID	118704753
InChi Key	UPZNTUYHCRQOIQ-UHFFFAOYSA-N
Smiles	FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCCCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Centrinone B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.58	50

Preparing Stock Solutions for Centrinone B

The following data is based on the product molecular weight 631.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.17 mL	15.83 mL	31.66 mL
2.5 mM	0.63 mL	3.17 mL	6.33 mL
5 mM	0.32 mL	1.58 mL	3.17 mL
25 mM	0.06 mL	0.32 mL	0.63 mL

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References for Centrinone B

References are publications that support the biological activity of the product.

Wong Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 2015 PMID: 25931445