Centrinone

Name: Centrinone
Brand: Tocris Bioscience
SKU: 5687
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5687

(1)

Citations (20)

COA / SDS

High affinity and selective PLK4 inhibitor

Key Product Details

Description:	High affinity and selective PLK4 inhibitor
Chemical Name:	2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	633.65

View Full Technical Details for Centrinone

Technical Data
Citations / Reviews (1)

Biological Activity for Centrinone

Centrinone is a high affinity and selective PLK4 inhibitor (K_i = 0.16 nM). Exhibits >1000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. Decreases expression of pluripotency markers and induces differentiation in pluripotent stem cells.

Licensing Information

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Technical Data for Centrinone

M. Wt	633.65
Formula	C₂₆H₂₅F₂N₇O₆S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1798871-30-3
PubChem ID	91801159
InChi Key	HHJSKDRCUMVWKF-UHFFFAOYSA-N
Smiles	FC1=C([N+]([O-])=O)C=CC=C1CS(C2=CC=C(SC3=NC(N4CCOCC4)=C(OC)C(NC5=NNC(C)=C5)=N3)C(F)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Centrinone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.68	50

Preparing Stock Solutions for Centrinone

The following data is based on the product molecular weight 633.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.16 mL	15.78 mL	31.56 mL
2.5 mM	0.63 mL	3.16 mL	6.31 mL
5 mM	0.32 mL	1.58 mL	3.16 mL
25 mM	0.06 mL	0.32 mL	0.63 mL

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References for Centrinone

References are publications that support the biological activity of the product.

Renzova Inactivation of PLK4-STIL module prevents self-renewal and triggers p53-dependent differentiation in human pluripotent stem cells. Stem Cell Reports. 2019 PMID: 30197118
Meitinger TRIM37 controls cancer-specific vulnerability to PLK4 inhibition. Nature. 2020 PMID: 32908304
Wong Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 2015 PMID: 25931445