Ceramide

Name: Ceramide
Brand: Tocris Bioscience
SKU: 0744

Tocris Bioscience, part of Bio-Techne | Catalog # 0744

Citations (27)

COA / SDS

Ser/Thr protein phosphatase activator

Key Product Details

Description:	Ser/Thr protein phosphatase activator
Chemical Name:	N-Acetylsphingosine
Molecular Weight:	341.53

View Full Technical Details for Ceramide

Technical Data
Citations

Biological Activity for Ceramide

Ceramide is a potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.

Compound Libraries for Ceramide

Ceramide is also offered as part of the Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Ceramide

M. Wt	341.53
Formula	C₂₀H₃₉NO₃
Storage	Desiccate at -20°C
CAS Number	3102-57-6
PubChem ID	5497136
InChi Key	BLTCBVOJNNKFKC-QUDYQQOWSA-N
Smiles	OC[C@@](NC(C)=O)([H])[C@H](O)/C([H])=C([H])/CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ceramide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	34.15	100
	DMSO	34.15	100

Preparing Stock Solutions for Ceramide

The following data is based on the product molecular weight 341.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.64 mL	29.28 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

Molarity Calculator

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Reconstitution Calculator

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References for Ceramide

References are publications that support the biological activity of the product.

Xie and Johnson Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 1997 PMID: 9282924
Kim Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-IF.. J.Biol.Chem. 1991 PMID: 1845977
Quintans Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 1994 PMID: 8048941
Dobowsky and Hannun Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 1992 PMID: 1312082