CGP 3466B maleate

Name: CGP 3466B maleate
Brand: Tocris Bioscience
SKU: 2966

Tocris Bioscience, part of Bio-Techne | Catalog # 2966

Citations (2)

COA / SDS

GAPDH inhibitor; neuroprotective

Key Product Details

Chemical Name:	N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate
Purity:	≥99%

View Full Technical Details for CGP 3466B maleate

Technical Data
Citations

Biological Activity for CGP 3466B maleate

CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H₂O₂ release. CGP 3466B inhibits colon cancer proliferation in vitro and displays neuroprotective activity in vivo.

Technical Data for CGP 3466B maleate

Formula	C₁₉H₁₇NO.C₄H₄O₄
Storage	Store at +4°C
Purity	≥99%
CAS Number	200189-97-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 3466B maleate

Solubility

Soluble Soluble to 10 mM in water and to 100 mM in DMSO

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CGP 3466B maleate

References are publications that support the biological activity of the product.

Guha P, Harraz M, Snyder S Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci U S A, 2016;113(5):1417-22. 2016 PMID: 26787898
Andringa et al. TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis., 2003;14:205 PMID: 14572443
Sagot et al. An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol., 2000;131:721 PMID: 11030721
Zoccarato et al. Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H₂O₂ release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr., 2008;40:289 PMID: 18763029

CGP 3466B maleate

Tocris Bioscience, part of Bio-Techne | Catalog # 2966

Key Product Details

Biological Activity for CGP 3466B maleate

Technical Data for CGP 3466B maleate

Solubility for CGP 3466B maleate

Dilution Calculator

Reconstitution Calculator

References for CGP 3466B maleate

Product Documents for CGP 3466B maleate

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected