CGP 71683 hydrochloride

Name: CGP 71683 hydrochloride
Brand: Tocris Bioscience
SKU: 2199

Tocris Bioscience, part of Bio-Techne | Catalog # 2199

Citations (8)

COA / SDS

Highly selective and potent non-peptide NPY Y5 receptor antagonist

Key Product Details

Description:	Highly selective and potent non-peptide NPY Y₅ receptor antagonist
Chemical Name:	N-[[trans-4-[[(4-Amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	512.07

View Full Technical Details for CGP 71683 hydrochloride

Technical Data
Citations

Biological Activity for CGP 71683 hydrochloride

CGP 71683 hydrochloride is an extremely selective, non-peptide NPY Y₅ receptor antagonist. Displays > 1000-fold selectivity over Y₁, Y₂ and Y₄ receptors; IC₅₀ values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y₅, Y₁, Y₂ and Y₄ receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats.

Compound Libraries for CGP 71683 hydrochloride

CGP 71683 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CGP 71683 hydrochloride

M. Wt	512.07
Formula	C₂₆H₂₉N₅O₂S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	192322-50-2
PubChem ID	9849276
InChi Key	DIQDKUNCSVFGHH-UHFFFAOYSA-N
Smiles	NC1=NC(NC[C@H]3CC[C@H](CNS(=O)(C4=CC=CC5=C4C=CC=C5)=O)CC3)=NC2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGP 71683 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.21	100

Preparing Stock Solutions for CGP 71683 hydrochloride

The following data is based on the product molecular weight 512.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.76 mL	19.53 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
10 mM	0.20 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for CGP 71683 hydrochloride

References are publications that support the biological activity of the product.

Dumont Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol. 2000 PMID: 10737674
Lecklin Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 2002 PMID: 11959807
Criscione Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y₅ receptor. J.Clin.Invest. 1998 PMID: 9854049