CGS 35066

Name: CGS 35066
Brand: Tocris Bioscience
SKU: 2512
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2512

(1)

Citations (9)

COA / SDS

Endothelin-converting enzyme (ECE) inhibitor

Key Product Details

Description:	Endothelin-converting enzyme (ECE) inhibitor
Chemical Name:	α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	349.28

View Full Technical Details for CGS 35066

Technical Data
Citations / Reviews (1)

Biological Activity for CGS 35066

CGS 35066 is a potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC₅₀ values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Technical Data for CGS 35066

M. Wt	349.28
Formula	C₁₆H₁₆NO₆P
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	261619-50-5
PubChem ID	9863167
InChi Key	CRUVAUSVWLATAE-ZDUSSCGKSA-N
Smiles	O=C([C@@H](NCP(O)(O)=O)CC1=CC3=C(C2=CC=CC=C2O3)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CGS 35066

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	34.92	100

Preparing Stock Solutions for CGS 35066

The following data is based on the product molecular weight 349.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.32 mL	28.63 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for CGS 35066

References are publications that support the biological activity of the product.

Trapani Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J.Cardiovasc.Pharmacol. 2000 PMID: 11078331
Kwan Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuropharmacol.Neurotoxicol.
De Lombaert Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 2000 PMID: 10669576