CHDI 00484077

Name: CHDI 00484077
Brand: Tocris Bioscience
SKU: 7879

Tocris Bioscience, part of Bio-Techne | Catalog # 7879

COA / SDS

Potent and selective HDAC class IIa inhibitor

Key Product Details

Description:	Potent and selective HDAC class IIa inhibitor
Chemical Name:	N-((R)-1-((S)-2-Methylpyrrolidin-1-yl)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	382.39

View Full Technical Details for CHDI 00484077

Technical Data
Citations

Biological Activity for CHDI 00484077

CHDI 00484077 is a potent and selective class IIa histone deacetylase HDAC inhibitor (IC₅₀ values = 10-30 nM in vivo, 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively). Exhibits 150-fold selectivity for class IIa over class I/IIb HDACs in cells. Orally bioavailable and CNS penetrant.

Licensing Information

Sold under license from CHDI Foundation

Technical Data for CHDI 00484077

M. Wt	382.39
Formula	C₁₈H₂₁F₃N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3025894-92-9
PubChem ID	162675553
InChi Key	DBWSFWPXCPNWRZ-NEPJUHHUSA-N
Smiles	O=C(C1=CC=C(C=C1)C2=NOC(C(F)(F)F)=N2)N[C@@H](CN3[C@H](CCC3)C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CHDI 00484077

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.24	100 with gentle warming
	ethanol	38.24	100 with gentle warming

Preparing Stock Solutions for CHDI 00484077

The following data is based on the product molecular weight 382.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.08 mL	26.15 mL
5 mM	0.52 mL	2.62 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for CHDI 00484077

References are publications that support the biological activity of the product.

Stott Evaluation of 5-(trifluoromethyl)-1,2,4-oxadiazole-based class IIa HDAC inhibitors for Huntington's disease. ACS Med.Chem.Lett 2021 PMID: 33738065