Cinacalcet hydrochloride

Name: Cinacalcet hydrochloride
Brand: Tocris Bioscience
SKU: 6170

Tocris Bioscience, part of Bio-Techne | Catalog # 6170

Citations (2)

COA / SDS

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Key Product Details

Description:	Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca²⁺ channel blocker; orally bioavailable
Alternative Names:	AMG 073
Chemical Name:	N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	393.87

View Full Technical Details for Cinacalcet hydrochloride

Technical Data
Citations

Biological Activity for Cinacalcet hydrochloride

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC₅₀ = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

Compound Libraries for Cinacalcet hydrochloride

Cinacalcet hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Cinacalcet hydrochloride

M. Wt	393.87
Formula	C₂₂H₂₂F₃N.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	364782-34-3
PubChem ID	156418
InChi Key	QANQWUQOEJZMLL-PKLMIRHRSA-N
Smiles	C[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cinacalcet hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.39	100

Preparing Stock Solutions for Cinacalcet hydrochloride

The following data is based on the product molecular weight 393.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for Cinacalcet hydrochloride

References are publications that support the biological activity of the product.

Ma Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 2011 PMID: 21239511
Goodman The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J.Am.Soc.Nephrol. 2002 PMID: 11912261