CIQ

Name: CIQ
Brand: Tocris Bioscience
SKU: 4105

Tocris Bioscience, part of Bio-Techne | Catalog # 4105

Citations (2)

COA / SDS

Potentiator of NMDA receptors containing GluN2C/GluN2D

Key Product Details

Description:	Potentiator of NMDA receptors containing GluN2C/GluN2D
Chemical Name:	(3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	467.94

View Full Technical Details for CIQ

Technical Data
Citations

Biological Activity for CIQ

CIQ is a subunit-selective potentiator of NMDA receptors containing the GluN2C (formally NR2C) or GluN2D (formally NR2D) subunit. Increases channel opening efficiency and enhances NMDA receptor responses.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for CIQ

CIQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CIQ

M. Wt	467.94
Formula	C₂₆H₂₆ClNO₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	486427-17-2
PubChem ID	4231127
InChi Key	VYMILMYEENZHAR-UHFFFAOYSA-N
Smiles	O=C(C3=CC(Cl)=CC=C3)N2C(COC4=CC=C(OC)C=C4)C1=CC(OC)=C(OC)C=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CIQ

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.79	100

Preparing Stock Solutions for CIQ

The following data is based on the product molecular weight 467.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.14 mL	10.69 mL	21.37 mL
5 mM	0.43 mL	2.14 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.14 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for CIQ

References are publications that support the biological activity of the product.

Mullasseril A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 2010 PMID: 20975674

CIQ