cis-6-Hydroxynorketamine hydrochloride

Name: cis -6-Hydroxynorketamine hydrochloride
Brand: Tocris Bioscience
SKU: 5982

Tocris Bioscience, part of Bio-Techne | Catalog # 5982

Citations (1)

COA / SDS

Enhances AMPA currents: antidepressant

Key Product Details

Description:	Enhances AMPA currents: antidepressant
Chemical Name:	cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	276.16

View Full Technical Details for cis-6-Hydroxynorketamine hydrochloride

Technical Data
Citations

Biological Activity for cis-6-Hydroxynorketamine hydrochloride

cis-6-Hydroxynorketamine hydrochloride is a metabolite of ketamine. Increases AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Exhibits antidepressive effects in vivo.

2S,6S-enantiomer and 2R,6R-enantiomer also available.

Technical Data for cis-6-Hydroxynorketamine hydrochloride

M. Wt	276.16
Formula	C₁₂H₁₄ClNO₂.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	2319601-04-0
PubChem ID	121513910
InChi Key	ZQJVHBJDLMIKJK-MHDYBILJSA-N
Smiles	ClC1=C([C@@]2(N)C([C@H](O)CCC2)=O)C=CC=C1.ClC3=C([C@]4(N)C([C@@H](O)CCC4)=O)C=CC=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for cis-6-Hydroxynorketamine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	27.62	100
	DMSO	27.62	100

Preparing Stock Solutions for cis-6-Hydroxynorketamine hydrochloride

The following data is based on the product molecular weight 276.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.11 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for cis-6-Hydroxynorketamine hydrochloride

References are publications that support the biological activity of the product.

Leung and Baillie Comparative pharmacology in the rat of KA and its two principal metabolites, norKA and (Z)-6-hydroxynorKA. J.Med.Chem. 1986 PMID: 3783598
Zanos NMDAR inhibition-independent antidepressant actions of KA metabolites. Nature 2016 PMID: 27144355