Citalopram hydrobromide

Name: Citalopram hydrobromide
Brand: Tocris Bioscience
SKU: 1427
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1427

(2)

Citations (52)

COA / SDS

Highly potent and selective 5-HT uptake inhibitor

Key Product Details

Description:	Highly potent and selective 5-HT uptake inhibitor
Chemical Name:	1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
Purity:	≥99% (HPLC)
Molecular Weight:	405.31

View Full Technical Details for Citalopram hydrobromide

Technical Data
Citations / Reviews (2)

Biological Activity for Citalopram hydrobromide

Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake (IC₅₀ values are 1.8, 8800 and 41000 nM respectively). Has negligible activity at a wide range of receptors.

Technical Data for Citalopram hydrobromide

M. Wt	405.31
Formula	C₂₀H₂₁FN₂O.HBr
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	59729-32-7
PubChem ID	77995
InChi Key	WIHMBLDNRMIGDW-UHFFFAOYSA-N
Smiles	Br.CN(C)CCCC1(OCC2=C1C=CC(=C2)C#N)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Citalopram hydrobromide

	Solvent	Max Conc. mM
Solubility
	ethanol	50
	water	10

Preparing Stock Solutions for Citalopram hydrobromide

The following data is based on the product molecular weight 405.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.93 mL	24.67 mL	49.34 mL
2.5 mM	0.99 mL	4.93 mL	9.87 mL
5 mM	0.49 mL	2.47 mL	4.93 mL
25 mM	0.10 mL	0.49 mL	0.99 mL

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References for Citalopram hydrobromide

References are publications that support the biological activity of the product.

Mateo Inhibition of 5-hydroxytryptamine reuptake by the antidepressant cital. in the locus coeruleus modulates the rat brain noradrenergic transmission in vivo. Neuropharmacology 2000 PMID: 10963747
Hyttel Citalopram - pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog.Drug Metabolism. Eds. Bridges, J. W. &amp; Ch
Auerbach and Hjorth Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor cital. on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn Schmiedebergs Arch.Pharmacol. 1995 PMID: 9053730