CL 82198 hydrochloride

Name: CL 82198 hydrochloride
Brand: Tocris Bioscience
SKU: 2632

Tocris Bioscience, part of Bio-Techne | Catalog # 2632

Citations (3)

COA / SDS

Selective inhibitor of MMP-13

Key Product Details

Description:	Selective inhibitor of MMP-13
Chemical Name:	N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	338.83

View Full Technical Details for CL 82198 hydrochloride

Technical Data
Citations

Biological Activity for CL 82198 hydrochloride

CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.

Compound Libraries for CL 82198 hydrochloride

CL 82198 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CL 82198 hydrochloride

M. Wt	338.83
Formula	C₁₇H₂₃N₂O₃.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1188890-36-9
PubChem ID	16760373
InChi Key	PIOACXKZWXHBRB-UHFFFAOYSA-N
Smiles	Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CL 82198 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	33.88	100
	DMSO	25.41	75

Preparing Stock Solutions for CL 82198 hydrochloride

The following data is based on the product molecular weight 338.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.95 mL	14.76 mL	29.51 mL
5 mM	0.59 mL	2.95 mL	5.90 mL
10 mM	0.30 mL	1.48 mL	2.95 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for CL 82198 hydrochloride

References are publications that support the biological activity of the product.

Borg IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75. Endocrine Abstr.
Lisse PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A 2016 PMID: 27035978
Chen Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc.