CORM 3

Name: CORM 3
Brand: Tocris Bioscience
SKU: 5320

Tocris Bioscience, part of Bio-Techne | Catalog # 5320

Citations (1)

COA / SDS

Water-soluble carbon monoxide-releasing molecule

Key Product Details

Chemical Name:

Tricarbonylchloro(glycinato)ruthenium

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Technical Data
Citations

Biological Activity for CORM 3

CORM 3 is a water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.

Technical Data for CORM 3

Formula	C₅H₄ClNO₅Ru
Storage	Store at -20°C
CAS Number	475473-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CORM 3

Solubility

Soluble Soluble to 100 mM in water

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References for CORM 3

References are publications that support the biological activity of the product.

Clark et al. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res., 2003;93:e2 PMID: 12842916
Foresti et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol., 2004;142:453 PMID: 15148243
Sawle et al. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol., 2005;145:800 PMID: 15880142
Bani-Hani et al. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther., 2006;318:1315 PMID: 16772536
Filippo et al. Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol., 2012;385:137 PMID: 22038495

CORM 3

Tocris Bioscience, part of Bio-Techne | Catalog # 5320

Key Product Details

Biological Activity for CORM 3

Technical Data for CORM 3

Solubility for CORM 3

Dilution Calculator

Reconstitution Calculator

References for CORM 3

Product Documents for CORM 3

COA

Certificate of Analysis

SDS

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