CP 316819

Name: CP 316819
Brand: Tocris Bioscience
SKU: 3542

Tocris Bioscience, part of Bio-Techne | Catalog # 3542

Citations (3)

COA / SDS

Selective glycogen phosphorylase inhibitor

Key Product Details

Description:	Selective glycogen phosphorylase inhibitor
Chemical Name:	5-Chloro-N-[(1S,2R)-2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	415.87

View Full Technical Details for CP 316819

Technical Data
Citations

Biological Activity for CP 316819

CP 316819 is a selective glycogen phosphorylase inhibitor [IC₅₀ values are 0.017 and 0.034 μM against human skeletal muscle glycogen phosphorylase a (huSMGPa) and liver glycogen phosphorylase a (huLGPa) respectively]. Antihyperglycemic agent.

Compound Libraries for CP 316819

CP 316819 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 316819

M. Wt	415.87
Formula	C₂₁H₂₂ClN₃O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	186392-43-8
PubChem ID	10273347
InChi Key	WEQLRDLTRCEUHG-PKOBYXMFSA-N
Smiles	O=C(N[C@@H](CC3=CC=CC=C3)[C@H](C(N(OC)C)=O)O)C2=CC1=CC(Cl)=CC=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 316819

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.59	100
	ethanol	41.59	100

Preparing Stock Solutions for CP 316819

The following data is based on the product molecular weight 415.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	12.02 mL	24.05 mL
5 mM	0.48 mL	2.40 mL	4.81 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for CP 316819

References are publications that support the biological activity of the product.

Freeman Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation site of the enzyme. Br.J.Pharmacol. 2006 PMID: 17016495
Suh Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-ca J.Pharmacol.Exp.Ther. 2007 PMID: 17251391
Baker Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle. Diabetes 2005 PMID: 16046314