CP 43

Name: CP 43
Brand: Tocris Bioscience
SKU: 6558

Tocris Bioscience, part of Bio-Techne | Catalog # 6558

Citations (2)

COA / SDS

Potent TAOK inhibitor

Key Product Details

Description:	Potent TAOK inhibitor
Chemical Name:	N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	384.47

View Full Technical Details for CP 43

Technical Data
Citations

Biological Activity for CP 43

CP 43 is a potent TAO kinase (TAOK) inhibitor (IC₅₀ values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.

Compound Libraries for CP 43

CP 43 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CP 43

M. Wt	384.47
Formula	C₂₅H₂₄N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	850467-66-2
PubChem ID	46673962
InChi Key	WQKXOAJVNFOHNZ-UHFFFAOYSA-N
Smiles	O=C(NC1CCCC2=CC=CC=C12)CNC(C3=CC=C(C4=CC=CC=C4)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 43

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.45	100
	ethanol	7.69	20

Preparing Stock Solutions for CP 43

The following data is based on the product molecular weight 384.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.60 mL	13.00 mL	26.01 mL
5 mM	0.52 mL	2.60 mL	5.20 mL
10 mM	0.26 mL	1.30 mL	2.60 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for CP 43

References are publications that support the biological activity of the product.

Giacomini A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies. Acta Neuropathol.Commun. 2018 PMID: 29730992
Koo Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells. Mol.Cancer Ther. 2017 PMID: 28830982