CP 93129 dihydrochloride

Name: CP 93129 dihydrochloride
Brand: Tocris Bioscience
SKU: 1032
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1032

(3)

Citations (15)

COA / SDS

5-HT1B agonist

Key Product Details

Description:	5-HT_1B agonist
Chemical Name:	1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
Molecular Weight:	288.18

View Full Technical Details for CP 93129 dihydrochloride

Technical Data
Citations / Reviews (3)

Biological Activity for CP 93129 dihydrochloride

CP 93129 dihydrochloride is a potent and highly selective 5-HT_1B agonist (K_i values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT_1B, 5-HT_1D, 5-HT_1A, 5-HT_1c and 5-HT₂, respectively). Reduces food intake and decreases body weight in rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 93129 dihydrochloride

M. Wt	288.18
Formula	C₁₂H₁₃N₃O.2HCl
Storage	Desiccate at RT
CAS Number	879089-64-2
PubChem ID	46927988
InChi Key	FLVJHUZZKVJQNH-UHFFFAOYSA-N
Smiles	Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 93129 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.82	100
	water	28.82	100

Preparing Stock Solutions for CP 93129 dihydrochloride

The following data is based on the product molecular weight 288.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.35 mL	34.70 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.74 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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Reconstitution Calculator

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References for CP 93129 dihydrochloride

References are publications that support the biological activity of the product.

Koe Biochemical and behavioral studies of the 5-HT_1B receptor agonist, CP-94,253. Drug Development Research
Hamid Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 2014 PMID: 24381287
Lee Infusion of the serotonin_1B (5-HT_1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 1998 PMID: 9566817