CP 94253 hydrochloride

Name: CP 94253 hydrochloride
Brand: Tocris Bioscience
SKU: 1317
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1317

(1)

Citations (10)

COA / SDS

Potent and selective 5-HT1B agonist

Key Product Details

Description:	Potent and selective 5-HT_1B agonist
Chemical Name:	5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	293.8

View Full Technical Details for CP 94253 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for CP 94253 hydrochloride

CP 94253 hydrochloride is a potent, selective 5-HT_1B agonist (K_i values are 89, 2, 860, 49 and 1,600 nM for 5-HT_1A, 5-HT_1B, 5-HT_1C, 5-HT_1D and 5-HT₂ receptors respectively). Centrally active upon systemic administration in vivo.

Compound Libraries for CP 94253 hydrochloride

CP 94253 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 94253 hydrochloride

M. Wt	293.8
Formula	C₁₅H₁₉N₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	845861-39-4
PubChem ID	11652258
InChi Key	PIIOXKQIZCVXMD-UHFFFAOYSA-N
Smiles	Cl.CCCOC1=CC=C2NC=C(C2=N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 94253 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	7.34	25
	DMSO	29.38	100

Preparing Stock Solutions for CP 94253 hydrochloride

The following data is based on the product molecular weight 293.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	17.02 mL	34.04 mL
5 mM	0.68 mL	3.40 mL	6.81 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for CP 94253 hydrochloride

References are publications that support the biological activity of the product.

Knobelman Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT_1A and 5-HT_1B receptors. J.Pharmacol.Exp.Ther. 2000 PMID: 10688630
Koe Biochemical and behavioral studies of the 5-HT_1B receptor agonist, CP-94,253. Drug Dev.Res.
Fish Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 1999 PMID: 10550489