CP 96345

Name: CP 96345
Brand: Tocris Bioscience
SKU: 2893

Tocris Bioscience, part of Bio-Techne | Catalog # 2893

Citations (14)

COA / SDS

Potent and selective NK1 antagonist

Key Product Details

Description:	Potent and selective NK₁ antagonist
Chemical Name:	(2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Purity:	≥98% (HPLC)
Molecular Weight:	412.57

View Full Technical Details for CP 96345

Technical Data
Citations

Biological Activity for CP 96345

CP 96345 is a potent and selective non-peptide NK₁ receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 96345

CP 96345 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 96345

M. Wt	412.57
Formula	C₂₈H₃₂N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	132746-60-2
PubChem ID	104943
InChi Key	FLNYLINBEZROPL-NSOVKSMOSA-N
Smiles	COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 96345

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.25	20 with gentle warming

Preparing Stock Solutions for CP 96345

The following data is based on the product molecular weight 412.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.12 mL	60.60 mL	121.19 mL
1 mM	2.42 mL	12.12 mL	24.24 mL
2 mM	1.21 mL	6.06 mL	12.12 mL
10 mM	0.24 mL	1.21 mL	2.42 mL

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References for CP 96345

References are publications that support the biological activity of the product.

Lembeck The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 1992 PMID: 1378337
Bang Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 2003 PMID: 12649350
Snider A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 1991 PMID: 1703323