CPI 203

Name: CPI 203
Brand: Tocris Bioscience
SKU: 5331

Tocris Bioscience, part of Bio-Techne | Catalog # 5331

(1)

Citations (2)

COA / SDS

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Key Product Details

Chemical Name:	(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for CPI 203

CPI 203 is a BET bromodomain inhibitor. Downregulates Myc expression, causes G₁ cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC₅₀ = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Also enhances fibroblast reprogramming to hiPSCs at low concentration. Orally bioavailable.

Technical Data for CPI 203

Formula	C₁₉H₁₈ClN₅OS
Storage	Store at -20°C
Purity	≥98%
CAS Number	1446144-04-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPI 203

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol

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References for CPI 203

References are publications that support the biological activity of the product.

Wong et al. The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis., 2014;5:e1450 PMID: 25299775
King et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell, 2013;153:1552 PMID: 23791182
Shao et al. Reprogramming by de-bookmarking the somatic transcriptional program through targeting of BET bromodomains. Cell Rep., 2016;16:3138 PMID: 27653680

CPI 203

Tocris Bioscience, part of Bio-Techne | Catalog # 5331

Key Product Details

Biological Activity for CPI 203

Technical Data for CPI 203

Solubility for CPI 203

Dilution Calculator

Reconstitution Calculator

References for CPI 203

Product Documents for CPI 203

COA

Certificate of Analysis

SDS

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