CPPG

Name: CPPG
Brand: Tocris Bioscience
SKU: 0972
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0972

(2)

Citations (105)

COA / SDS

Potent group III mGlu antagonist

Key Product Details

Description:	Potent group III mGlu antagonist
Chemical Name:	(RS)-α-Cyclopropyl-4-phosphonophenylglycine
Purity:	≥98% (HPLC)
Molecular Weight:	271.21

View Full Technical Details for CPPG

Technical Data
Citations / Reviews (2)

Biological Activity for CPPG

CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC₅₀ values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (K_B = 0.65 ± 0.07 nM).

Technical Data for CPPG

M. Wt	271.21
Formula	C₁₁H₁₄NO₅P
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	183364-82-1
PubChem ID	2878
InChi Key	IGODGTDUQSMDQU-UHFFFAOYSA-N
Smiles	NC(C2CC2)(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPPG

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	27.12	100

Preparing Stock Solutions for CPPG

The following data is based on the product molecular weight 271.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.69 mL	18.44 mL	36.87 mL
5 mM	0.74 mL	3.69 mL	7.37 mL
10 mM	0.37 mL	1.84 mL	3.69 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for CPPG

References are publications that support the biological activity of the product.

Toms The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. BrJ.Pharmacol. 1996 PMID: 8922731
Kemp α-Methyl-3-phosphonophenylglycine and α-cyclopropyl-4-phosphonophenylglycine are potent antagonists at mGluRs negatively coupled to adenylyl cyclase. Br.J.Pharmacol.
Jane Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology 1996 PMID: 9121605