CPYPP

Name: CPYPP
Brand: Tocris Bioscience
SKU: 4568

Tocris Bioscience, part of Bio-Techne | Catalog # 4568

(1)

Citations (7)

COA / SDS

DOCK2-Rac1 interaction inhibitor

Key Product Details

Chemical Name:	4-[3-(2-Chlorophenyl)-2-propen-1-ylidene]-1-phenyl-3,5-pyrazolidinedione
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for CPYPP

CPYPP is a DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitro and in vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro.

Technical Data for CPYPP

Formula	C₁₈H₁₃ClN₂O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	310460-39-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPYPP

Solubility

Soluble Soluble to 20 mM in DMSO

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References for CPYPP

References are publications that support the biological activity of the product.

Nishikimi et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol., 2012;19:488 PMID: 22520755
Laurin et al. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A., 2013;110:7434 PMID: 23592719

CPYPP

Tocris Bioscience, part of Bio-Techne | Catalog # 4568

Key Product Details

Biological Activity for CPYPP

Technical Data for CPYPP

Solubility for CPYPP

Dilution Calculator

Reconstitution Calculator

References for CPYPP

Product Documents for CPYPP

COA

Certificate of Analysis

SDS

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