CST 530

Name: CST 530
Brand: Tocris Bioscience
SKU: 8065

Tocris Bioscience, part of Bio-Techne | Catalog # 8065

COA / SDS

Monovalent IAP antagonist

Key Product Details

Description:	Monovalent IAP antagonist
Chemical Name:	(2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity:	≥97% (HPLC)
Molecular Weight:	560.74

View Full Technical Details for CST 530

Technical Data
Citations

Biological Activity for CST 530

CST 530 is a monovalent IAP antagonist. Induces potent cIAP1 autodegradation and mild cIAP2 depletion. CST 530 reduces cell viability in a variety of cancer cell lines including SUDHL6, MOLM13 and HEL (IC₅₀ values are 170 nM, 420 nM and 450 nM respectively).

Technical Data for CST 530

M. Wt	560.74
Formula	C₃₃H₄₄N₄O₄
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	847137-53-5
InChi Key	GUOVHJVNYPRNQS-SHUILBLCSA-N
Smiles	CN[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CST 530

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.07	100

Preparing Stock Solutions for CST 530

The following data is based on the product molecular weight 560.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.92 mL	17.83 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for CST 530

References are publications that support the biological activity of the product.

Ng Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 2023 PMID: 36996313