CST 626

Name: CST 626
Brand: Tocris Bioscience
SKU: 8021

Tocris Bioscience, part of Bio-Techne | Catalog # 8021

COA / SDS

Potent pan IAP Degrader (PROTAC®)

Key Product Details

Description:	Potent pan IAP Degrader (PROTAC^®)
Chemical Name:	(2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1103.43

View Full Technical Details for CST 626

Technical Data
Citations

Biological Activity for CST 626

CST 626 is a potent IAP Degrader (PROTAC^®) (DC₅₀ values at 16 hours are 0.7 nM, 2.4 nM and 6.2 nM at XIAP, cIAP1 and cIAP2 respectively; D_max = 90-99%). Reduces cell viability in some cell types, including SUDHL6 and MOLM13 (IC₅₀ values are 16 nM and 21 nM respectively).

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for CST 626

M. Wt	1103.43
Formula	C₆₁H₈₂N₈O₉S
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	SMENADKMMXTZAZ-FMVATYOPSA-N
Smiles	O=C([C@H]1N(C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)C[C@@H](OC3=CC(OCCCCC(N[C@H](C(N4C[C@H](O)C[C@H]4C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)=O)C(C)(C)C)=O)=CC=C3)C1)N[C@@H]7CCCC8=CC=CC=C87

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CST 626

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	110.34	100

Preparing Stock Solutions for CST 626

The following data is based on the product molecular weight 1103.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.91 mL	4.53 mL	9.06 mL
5 mM	0.18 mL	0.91 mL	1.81 mL
10 mM	0.09 mL	0.45 mL	0.91 mL
50 mM	0.02 mL	0.09 mL	0.18 mL

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References for CST 626

References are publications that support the biological activity of the product.

Ng Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 2023 PMID: 36996313