CTOP

Tocris Bioscience, part of Bio-Techne | Catalog # 1578

COA / SDS

Potent and selective μ antagonist

Key Product Details

Description:	Potent and selective μ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1062.28

View Full Technical Details for CTOP

Technical Data
Citations

Biological Activity for CTOP

CTOP is a potent and selective μ opioid receptor antagonist (K_i values are 0.96 and >10,000 nM for μ and δ receptors respectively). Causes behavioral effects on central administration in vivo. Also increases K⁺ currents in rat locus ceruleus neurons in vitro via a μ receptor independent mechanism.

Technical Data for CTOP

M. Wt	1062.28
Formula	C₅₀H₆₇N₁₁O₁₁S₂
Single Letter Sequence	FCYWXTXT (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X-5 = Orn, X-7 = Pen, Disulfide bridge: 2-7, Thr-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	103429-31-8
PubChem ID	90479805
InChi Key	PZWWYAHWHHNCHO-KOFBULAQSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC(C)(C)C(NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CTOP

Solubility

Soluble to 1mg/ml in water

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References for CTOP

References are publications that support the biological activity of the product.

Chieng The μ-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a no Mol.Pharmacol. 1996 PMID: 8794906
Gulya Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH² (CTOP) in mice. Eur.J.Pharmacol. 1988 PMID: 2901358
Hawkins [³H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH₂] ([³H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain. J.Pharmacol.Exp.Ther. 1989 PMID: 2563293
Badiani Intra-VTA injections of the mu-opioid antagonist CTOP enhance locomotor activity. Brain Res. 1995 PMID: 7496796