CU-76

Name: CU-76
Brand: Tocris Bioscience
SKU: 7820

Tocris Bioscience, part of Bio-Techne | Catalog # 7820

COA / SDS

Selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Key Product Details

Description:	Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Chemical Name:	Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	407.12

View Full Technical Details for CU-76

Technical Data
Citations

Biological Activity for CU-76

CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC₅₀ = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.

Technical Data for CU-76

M. Wt	407.12
Formula	C₁₁H₈F₂IN₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2400954-58-5
PubChem ID	156588964
InChi Key	DATILFYUDSRBBK-UHFFFAOYSA-N
Smiles	O=C(C1=NC(NC2=CC(F)=C(C(F)=C2)I)=NC(N)=N1)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CU-76

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.71	100
	ethanol	4.07	10

Preparing Stock Solutions for CU-76

The following data is based on the product molecular weight 407.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.28 mL	24.56 mL
5 mM	0.49 mL	2.46 mL	4.91 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for CU-76

References are publications that support the biological activity of the product.

Li Therapeutic development by targeting the cGAS-STING pathway in autoimmune disease and cancer. Front Pharmacol 2021 PMID: 34867409
Wang Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors. Bioorg.Med.Chem.Lett 2021 PMID: 33984476
Salinas Discovery of small-molecule cyclic GMP-AMP synthase inhibitors. J.Org.Chem 2020 PMID: 31829590