CW 008

Name: CW 008
Brand: Tocris Bioscience
SKU: 5495

Tocris Bioscience, part of Bio-Techne | Catalog # 5495

Citations (6)

COA / SDS

PKA signaling activator; promotes osteogenesis from hMSCs

Key Product Details

Description:	PKA signaling activator; promotes osteogenesis from hMSCs
Chemical Name:	4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	420.37

View Full Technical Details for CW 008

Technical Data
Citations

Biological Activity for CW 008

CW 008 is a cAMP/PKA/CREB pathway activator. Promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro. Increases bone mass and bone volume density in ovariectomized mice.

Compound Libraries for CW 008

CW 008 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for CW 008

M. Wt	420.37
Formula	C₂₁H₁₄F₂N₆O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1134613-19-6
PubChem ID	59528098
InChi Key	KCIMKTNQCUDTFI-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(F)C=C1)NC2=NNC3=NC(C4=C5N(C=CC(OC)=C5)N=C4)=C(F)C=C32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CW 008

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.02	50

Preparing Stock Solutions for CW 008

The following data is based on the product molecular weight 420.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.76 mL	23.79 mL	47.58 mL
2.5 mM	0.95 mL	4.76 mL	9.52 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
25 mM	0.10 mL	0.48 mL	0.95 mL

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References for CW 008

References are publications that support the biological activity of the product.

Kim An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J.Cell.Physiol. 2013 PMID: 22886506