CY 09

Name: CY 09
Brand: Tocris Bioscience
SKU: 6436

Tocris Bioscience, part of Bio-Techne | Catalog # 6436

Citations (2)

COA / SDS

NLRP3 inhibitor; active in vivo

Key Product Details

Description:	NLRP3 inhibitor; active in vivo
Chemical Name:	4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	423.43

View Full Technical Details for CY 09

Technical Data
Citations

Biological Activity for CY 09

CY 09 is a NLRP3 inhibitor (K_d = 500 nM); directly binds to ATP-binding motif of NLRP3 NACHT domain. Blocks NLRP3 inflammasome assembly and activation. Displays therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes. Exhibits no activity for hERG (10 μM).

Technical Data for CY 09

M. Wt	423.43
Formula	C₁₉H₁₂F₃NO₃S2
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1073612-91-5
PubChem ID	44561595
InChi Key	DJTINRHPPGAPLD-DHDCSXOGSA-N
Smiles	OC(C1=CC=C(C=C1)/C=C2SC(N(C/2=O)CC3=CC(C(F)(F)F)=CC=C3)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CY 09

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.47	20 with gentle warming

Preparing Stock Solutions for CY 09

The following data is based on the product molecular weight 423.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.81 mL	59.04 mL	118.08 mL
1 mM	2.36 mL	11.81 mL	23.62 mL
2 mM	1.18 mL	5.90 mL	11.81 mL
10 mM	0.24 mL	1.18 mL	2.36 mL

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References for CY 09

References are publications that support the biological activity of the product.

Jiang Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J.Exp.Med. 2017 PMID: 29021150