CyPPA

Name: CyPPA
Brand: Tocris Bioscience
SKU: 2953
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2953

(1)

Citations (20)

COA / SDS

KCa2.2 and KCa2.3 (SK) channel activator

Key Product Details

Description:	K_Ca2.2 and K_Ca2.3 (SK) channel activator
Chemical Name:	N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
Purity:	≥99% (HPLC)
Molecular Weight:	285.39

View Full Technical Details for CyPPA

Technical Data
Citations / Reviews (1)

Biological Activity for CyPPA

CyPPA is an activator of small conductance Ca²⁺-activated K⁺ channels that displays selectivity for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels (EC₅₀ values are 5.6 and 14 μM for K_Ca2.3 and K_Ca2.2 respectively). Displays no activity at K_Ca2.1 (SK1) and K_Ca3.1 (IK) channels.

Technical Data for CyPPA

M. Wt	285.39
Formula	C₁₆H₂₃N₅
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	73029-73-9
PubChem ID	909822
InChi Key	USEMRPYUFJNFQN-UHFFFAOYSA-N
Smiles	CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for CyPPA

References are publications that support the biological activity of the product.

Hougaard Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca²⁺-activated K⁺ channels. Br.J.Pharmacol. 2007 PMID: 17486140

CyPPA

Tocris Bioscience, part of Bio-Techne | Catalog # 2953

Key Product Details

Biological Activity for CyPPA

Technical Data for CyPPA

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for CyPPA

Product Documents for CyPPA

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected