Cytochalasin D

Name: Cytochalasin D
Brand: Tocris Bioscience
SKU: 1233
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1233

(1)

Citations (112)

COA / SDS

Disrupts actin filament function

Key Product Details

Description:	Disrupts actin filament function
Alternative Names:	Zygosporin A
Chemical Name:	(7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione
Purity:	≥95% (HPLC)
Molecular Weight:	507.63

View Full Technical Details for Cytochalasin D

Technical Data
Citations / Reviews (1)

Biological Activity for Cytochalasin D

Cytochalasin D is a potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B (Cat. No. 5474), does not inhibit monosaccharide transport across the plasma membrane.

Technical Data for Cytochalasin D

M. Wt	507.63
Formula	C₃₀H₃₇NO₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	22144-77-0
PubChem ID	98137101
InChi Key	SDZRWUKZFQQKKV-HYKYWQBKSA-N
Smiles	C=C([C@H]4C)[C@@H](O)[C@]([C@@]1([C@H](OC(C)=O)/C=C/[C@@](O)3C)[C@]4([H])[C@@H](CC2=CC=CC=C2)N[C@]1=O)([H])/C=C/C[C@H](C)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cytochalasin D

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5	with gentle warming
	DMSO	25

Preparing Stock Solutions for Cytochalasin D

The following data is based on the product molecular weight 507.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.94 mL	19.70 mL	39.40 mL
2.5 mM	0.79 mL	3.94 mL	7.88 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

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References for Cytochalasin D

References are publications that support the biological activity of the product.

Carlier Interaction of cytochalasin D with actin filaments in the presence of ADP and ATP. J.Biol.Chem. 1986 PMID: 3944126
Stevenson and Begg Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells. J.Cell Sci. 1994 PMID: 8006058
Abedi and Zachary Cytochalasin D stimulation of tyrosine phosphorylation and phosphotyrosine-associated kinase activity in vascular smooth muscle cells. Biochem.Biophys.Res.Commun. 1998 PMID: 9588169