Darapladib

Name: Darapladib
Brand: Tocris Bioscience
SKU: 6755

Tocris Bioscience, part of Bio-Techne | Catalog # 6755

COA / SDS

Potent lp-PLA2 inhibitor

Key Product Details

Description:	Potent lp-PLA₂ inhibitor
Chemical Name:	N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	666.77

View Full Technical Details for Darapladib

Technical Data
Citations

Biological Activity for Darapladib

Darapladib is a potent lipoprotein-associated phospholipase A₂ (lp-PLA₂) inhibitor (IC₅₀ = 5 nM in whole human plasma).

Compound Libraries for Darapladib

Darapladib is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Darapladib

M. Wt	666.77
Formula	C₃₆H₃₈F₄N₄O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	356057-34-6
PubChem ID	9939609
InChi Key	WDPFJWLDPVQCAJ-UHFFFAOYSA-N
Smiles	CCN(CCN(C(CN1C2=C(C(N=C1SCC3=CC=C(C=C3)F)=O)CCC2)=O)CC4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Darapladib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	66.68	100
	ethanol	66.68	100

Preparing Stock Solutions for Darapladib

The following data is based on the product molecular weight 666.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.50 mL	7.50 mL	15.00 mL
5 mM	0.30 mL	1.50 mL	3.00 mL
10 mM	0.15 mL	0.75 mL	1.50 mL
50 mM	0.03 mL	0.15 mL	0.30 mL

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Reconstitution Calculator

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References for Darapladib

References are publications that support the biological activity of the product.

Blackie The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A₂. Bioorg.Med.Chem.Lett. 2003 PMID: 12643913