Daunorubicin hydrochloride

Name: Daunorubicin hydrochloride
Brand: Tocris Bioscience
SKU: 1467
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1467

(1)

Citations (12)

COA / SDS

DNA topoisomerase II inhibitor

Key Product Details

Description:	DNA topoisomerase II inhibitor
Alternative Names:	Daunomycin
Chemical Name:	(8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	563.99

View Full Technical Details for Daunorubicin hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Daunorubicin hydrochloride

Daunorubicin hydrochloride is a DNA topoisomerase II inhibitor. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.Anticancer agent. Exhibits activity against nonlymphocytic leukemia. Identified as targeting human host proteins that interact with SARS-CoV-2. Also enhances adeno-associated virus transduction of HeLa cells in vitro.

Technical Data for Daunorubicin hydrochloride

M. Wt	563.99
Formula	C₂₇H₂₉NO₁₀.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	23541-50-6
PubChem ID	3085106
InChi Key	GUGHGUXZJWAIAS-CFCXLQPVSA-N
Smiles	NC1CC(O[C@H]2C[C@@]([C@@](C)=O)(O)CC3=C2C(O)=C5C(C(C4=CC=CC(OC)=C4C5=O)=O)=C3O)OC(C)C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Daunorubicin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		50

Preparing Stock Solutions for Daunorubicin hydrochloride

The following data is based on the product molecular weight 563.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.55 mL	17.73 mL	35.46 mL
2.5 mM	0.71 mL	3.55 mL	7.09 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
25 mM	0.07 mL	0.35 mL	0.71 mL

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References for Daunorubicin hydrochloride

References are publications that support the biological activity of the product.

Gordon A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 2020 PMID: 32353859
Pommier DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem.Biol. 2010 PMID: 20534341
Nicolson Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 2016 PMID: 27147738
Dickey Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 2006 PMID: 16930453
Laurent and Jaffrezou Signaling pathways activated by daunoru. Blood 2001 PMID: 11493433
Gewirtz A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru. Biochem.Pharmacol. 1999 PMID: 10075079
Aubel-Sadron and Londos-Gagliardi Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 1984 PMID: 6380596

Product Documents for Daunorubicin hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Daunorubicin hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov