DBM 1285 dihydrochloride

Name: DBM 1285 dihydrochloride
Brand: Tocris Bioscience
SKU: 5095

Tocris Bioscience, part of Bio-Techne | Catalog # 5095

COA / SDS

p38 MAPK inhibitor; anti-inflammatory

Key Product Details

Description:	p38 MAPK inhibitor; anti-inflammatory
Chemical Name:	N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	468.42

View Full Technical Details for DBM 1285 dihydrochloride

Technical Data
Citations

Biological Activity for DBM 1285 dihydrochloride

DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo. Attenuates zymosan-induced inflammation and adjuvant-induced arthritis in murine models. Orally active.

Technical Data for DBM 1285 dihydrochloride

M. Wt	468.42
Formula	C₂₁H_22FN₅S.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1782532-29-9
PubChem ID	90489008
InChi Key	ANQWETXPBPZVOF-UHFFFAOYSA-N
Smiles	FC(C=C4)=CC=C4C1=C(C2=CC=NC(NC5CC5)=N2)SC(C3CCNCC3)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DBM 1285 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	46.84	100

Preparing Stock Solutions for DBM 1285 dihydrochloride

The following data is based on the product molecular weight 468.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.67 mL	21.35 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for DBM 1285 dihydrochloride

References are publications that support the biological activity of the product.

Kang DBM1285 suppresses tumor necrosis factor α production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway. J.Pharmacol.Exp.Ther. 2010 PMID: 20427474