DC 260126

Name: DC 260126
Brand: Tocris Bioscience
SKU: 5357

Tocris Bioscience, part of Bio-Techne | Catalog # 5357

Citations (18)

COA / SDS

FFA1 (GPR40) antagonist

Key Product Details

Chemical Name:	N-(4-Butylphenyl)-4-fluorobenzenesulfonamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for DC 260126

DC 260126 is a free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca²⁺ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Technical Data for DC 260126

Formula	C₁₆H₁₈FNO₂S
Storage	Store at -20°C
Purity	≥98%
CAS Number	346692-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DC 260126

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for DC 260126

References are publications that support the biological activity of the product.

Zhang et al. DC260126, a small-molecule antagonist of GPR40, improves Ins tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother., 2010;64:647 PMID: 20888730
Hu et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm., 2009;390:557 PMID: 19818732
Sun et al. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE, 2013;8:e66744 PMID: 23776696

DC 260126

Tocris Bioscience, part of Bio-Techne | Catalog # 5357

Key Product Details

Biological Activity for DC 260126

Technical Data for DC 260126

Solubility for DC 260126

Dilution Calculator

Reconstitution Calculator

References for DC 260126

Product Documents for DC 260126

COA

Certificate of Analysis

SDS

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