DCPIB

Name: DCPIB
Brand: Tocris Bioscience
SKU: 1540
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1540

(1)

Citations (85)

COA / SDS

Blocker of VRAC/ICl, swell

Key Product Details

Description:	Blocker of VRAC/I_{Cl, swell}
Alternative Names:	SN-401
Chemical Name:	4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	427.37

View Full Technical Details for DCPIB

Technical Data
Citations / Reviews (1)

Biological Activity for DCPIB

DCPIB is a volume-regulated anion channel (VRAC) blocker (IC₅₀ ~ 2 μM in rat pancreatic β-cells). Also blocks I_Cl,swell in various cardiovascular tissues (IC₅₀ = 4.1 μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect K_ATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Also activates TREK1 and TRAAK K⁺ channels and inhibits TRESK, TASK1 and TASK3 K⁺ channels at 10 μM, in vitro. Also inhibits VRAC-mediated 2'3'-cyclic-GMP-AMP (cGAMP) transport.

Technical Data for DCPIB

M. Wt	427.37
Formula	C₂₂H₂₈Cl₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	82749-70-0
PubChem ID	10071166
InChi Key	KHKGTPJPBOQECW-UHFFFAOYSA-N
Smiles	CCCCC1(CC2=C(C1=O)C(Cl)=C(Cl)C(OCCCC(O)=O)=C2)C1CCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DCPIB

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	ethanol	42.74	100

Preparing Stock Solutions for DCPIB

The following data is based on the product molecular weight 427.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.70 mL	23.40 mL
5 mM	0.47 mL	2.34 mL	4.68 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for DCPIB

References are publications that support the biological activity of the product.

Lahey LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 2020 PMID: 33171122
Lv DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K_2P channels. ACS.Chem.Neurosci. 2019 PMID: 30935201
Decher DCPIB is a novel selective blocker of I_Cl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 2001 PMID: 11724753
Best Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 2004 PMID: 15063150
Bourke Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 1981 PMID: 6267227